SBG logo - series of images from protein expression through to the design of novel active site inhibitors

Welcome to Structural Biochemistry @ Edinburgh

Image of the Michael Swann Building This is the new website for the Structural Biochemistry Group. Based in purpose built research laboratories within the Michael Swann building on the University of Edinburgh's King's Buildings campus the SBG is home to a collection of independent research groups united by their common interest in the structure and function of biological molecules.

The group has an international mix of personnel and expertise in protein expression and purification as well as protein structure determination by X-ray crystallography and NMR. Our research interests are broad and range from the rational design of novel inhibitors for cell cycle kinases to the structure and function of membrane proteins.

Via this website you can learn more about the research activities of the individual laboratories within the group. You can also browse some of the many protein structures that have been determined by our researchers or view current opportunities for study or employment.

Featured Structure

Leishmania mexicana - pyruvate kinase

Comparison of the structures of Leishmania mexicana pyruvate kinase in its inactive T-state (blue) with that of a putative R-state (yellow). It can be seen that the major differences occur in the B-domain at the bottom of the diagram. The active site is located between the B-domain and the adjacent A-domain that is folded into an 8-fold alpha-beta barrel.

The parasite and human enzymes have different allosteric activators, and the consequential differences at the effector site (in the C-domain top left of diagram) provide opportunities for the development of parasite-specific inhibitors.

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<i>Leishmania mexicana</i> - pyruvate kinase structure

Full details of this structure can be found here

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