SBG logo - series of images from protein expression through to the design of novel active site inhibitors

Welcome to Structural Biochemistry @ Edinburgh

Image of the Michael Swann Building This is the new website for the Structural Biochemistry Group. Based in purpose built research laboratories within the Michael Swann building on the University of Edinburgh's King's Buildings campus the SBG is home to a collection of independent research groups united by their common interest in the structure and function of biological molecules.

The group has an international mix of personnel and expertise in protein expression and purification as well as protein structure determination by X-ray crystallography and NMR. Our research interests are broad and range from the rational design of novel inhibitors for cell cycle kinases to the structure and function of membrane proteins.

Via this website you can learn more about the research activities of the individual laboratories within the group. You can also browse some of the many protein structures that have been determined by our researchers or view current opportunities for study or employment.

Featured Structure

Ocr from bacteriophage T7

We have solved, by X-ray crystallography to a resolution of 1.8 A, the structure of a protein capable of mimicking approximately 20 base pairs of B-form DNA. This ocr protein, encoded by gene 0.3 of bacteriophage T7, mimics the size and shape of a bent DNA molecule and the arrangement of negative charges along the phosphate backbone of B-form DNA. We also demonstrate that ocr is an efficient inhibitor in vivo of all known families of the complex type I DNA restriction enzymes. Using atomic force microscopy, we have also observed that type 1 enzymes induce a bend in DNA of similar magnitude to the bend in the ocr molecule. This first structure of an antirestriction protein demonstrates the construction of structural mimetics of long segments of B-form DNA.......

Ocr from bacteriophage T7 structure

Full details of this structure can be found here

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