SBG logo - series of images from protein expression through to the design of novel active site inhibitors

Welcome to Structural Biochemistry @ Edinburgh

Image of the Michael Swann Building This is the new website for the Structural Biochemistry Group. Based in purpose built research laboratories within the Michael Swann building on the University of Edinburgh's King's Buildings campus the SBG is home to a collection of independent research groups united by their common interest in the structure and function of biological molecules.

The group has an international mix of personnel and expertise in protein expression and purification as well as protein structure determination by X-ray crystallography and NMR. Our research interests are broad and range from the rational design of novel inhibitors for cell cycle kinases to the structure and function of membrane proteins.

Via this website you can learn more about the research activities of the individual laboratories within the group. You can also browse some of the many protein structures that have been determined by our researchers or view current opportunities for study or employment.

Featured Structure

Trypanosoma brucei - Phosphofructokinase

The tetrameric structure of phosphofructokinase from Trypanosoma brucei. The N-terminal domains from two subunits shown overlapping at the left of the figure appear to function as "embracing arms" between neighbouring subunits, and the helical "reaching arms" shown at the bottom of the figure become ordered when a ligand (substrate or activator) is bound, thereby bringing opposite subunits together. Both regions help to stabilise the quaternary structure. The figure is taken from a paper in preparation: Vasquez-Valdivieso et al, "The allosteric mechanism of Trypanosoma brucei phosphofructokinase".

A close up of the effector......

<i>Trypanosoma brucei</i> - Phosphofructokinase structure

Full details of this structure can be found here

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