SBG logo - series of images from protein expression through to the design of novel active site inhibitors

Welcome to Structural Biochemistry @ Edinburgh

Image of the Michael Swann Building This is the new website for the Structural Biochemistry Group. Based in purpose built research laboratories within the Michael Swann building on the University of Edinburgh's King's Buildings campus the SBG is home to a collection of independent research groups united by their common interest in the structure and function of biological molecules.

The group has an international mix of personnel and expertise in protein expression and purification as well as protein structure determination by X-ray crystallography and NMR. Our research interests are broad and range from the rational design of novel inhibitors for cell cycle kinases to the structure and function of membrane proteins.

Via this website you can learn more about the research activities of the individual laboratories within the group. You can also browse some of the many protein structures that have been determined by our researchers or view current opportunities for study or employment.

Featured Structure

Leishmania mexicana Phosphoglycerate mutase

Phosphoglycerate mutase from Leishmania mexicana. A ball-and-stick representation of the substrate 3-phosphoglycerate is shown at the active site that is located between the domains of this monomeric enzyme. The sphere at the active site is a cobalt ion, and is required for activity. The other sphere near the periphery of the enzyme is a sodium ion that may help to stabilise the enzyme.

This enzyme is a particularly good target for structure-based drug design because it is not homologous with the corresponding PGAM from the human host. These two enzymes share no common structural or mechanistic features.

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<i>Leishmania mexicana</i> Phosphoglycerate mutase structure

Full details of this structure can be found here

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